Formulasi Sediaan Gel Ekstrak Etanol Bunga Soka (Ixora coccinea L) Sebagai Terapi Infeksi Pada Kulit Yang Disebabkan Oleh Bakteri Staphyloccocus aureus
DOI:
https://doi.org/10.33143/jhtm.v6i2.1955Abstract
Penelitian tentang pemanfaatan tanaman sebagai obat telah banyak dilakukan salah satunya tanaman soka (Ixora coccinea L.). Ekstrak etanol dari bunga soka (Ixora coccinea L.) memiliki kandungan flavonoid, alkaloid, glikosida, terpenoid dan karbohidrat. Data rata-rata selisih diameter sebelum dan sesudah diolesi gel ekstrak etanol bunga asoka dianalisis secara deskriptif, penyembuhan infeksi dinilai dengan parameter diameter luka pada infeksi dan berapa hari luka sembuh total. Semakin kecil diameter luka pada infeksi semakin baik penyembuhan yang terjadi, Formulasi yang bagus untuk penyembuhan infeksi adalah gel konsentrasi 10% ekstrak bunga soka yang terbukti dapat menyembuhkan luka infeksi pada mencit dengan dilihat pengurangan diameter luka sampai hari 11. Hasil pengujian stabilitas gel memenuhi syarat untuk sediaan gel yaitu homogenitas daya lekat, daya sebar dan uji pH.
Kata kunci: Bunga soka (Ixora Coccinea L.), Infeksi luka, Gel ekstrak bunga soka.
A lot of research has been conducted on the use of plants as drugs, and one of them is Ashoka (Ixora coccinea L.). Ethanol extract from Ashoka flower (Ixora coccinea L.) contains flavonoids, alkaloids, glycosides, terpenoids, and carbohydrates. The data on the average diameter difference, before and after applying the Ashoka ethanol extract gel, were analyzed descriptively, infection healing was assessed by the diameter of the wound in the infection and by the number of days required by the wound to recover. The smaller the wound diameter in infection, the better the healing process is. The best formulation for healing infection is at 10% concentration of Ashoka flower extract gel. It was proven to cure infection wounds in mice based on the reduction of the wound diameter by Day 11. The results of the stability test on the gel show that homogeneity, adhesivity, spreadability, and pH have met the requirements for the gel preparations.
Keywords: Ashoka flower (Ixora coccinea L.), Infection wound,
                   extract gel of Ashoka flower
References
Ansel C,Howard. (2005). Pengantar Bentuk sediaan Farmasi, Edisi IV, universitas Indonesia, Jakarta.
Hariana Arif H. (2013) Tumbuhan obat dan khasiatnya Jakarta : penebar swadaya
Navolthula R, Merugu, R. & Rudra, M.P.P. (2015). Phytocemical Analysis, Syntesis, antitumor and antimicrobial activity of silver Nanoparticles using flower extracts of ixora coccine. International Journal of chemtech Research. 7(5) : 2374-2380.
Panche A.N, A.D Diwan et al., (2016). Flavonoid : an overview. Journal of nutritional science. 5(47) : 1-15
Triana Desi. (2014) Frekuensi β- Lactamase Hasil Staphloccocus aureus secara iodometri Di laboratorium mikrobiologi Fakultas Kedokteran Universitas Andalas. Jurnal Gradien, 10 (2) : 992-995
. (2008). Farmakope Herbal Indonesia, derektorat jendral pengawasan obat dan makanan, Jakarta, Indonesia
Latifah. (2015). Idenrifikasi golongan senyawa flavonoid dan uji aktivitas antioksidan pada ekstrak rimpang kencur kaempferia galangal L. dengan metode DPPH (1,1 Difenil-2 pikrilhidrazil), skripsi, fakultas sains dan teknologi universitas islam negri maulana malik Ibrahim, malang.
Hammado nurrurahmah, Illing Ilmiati. (2013). Identifikasi senyawa bahan aktif alkaloid pada tanaman lahuna (Eupatorium odoratum). Jurnal dinamika. 4(2) : 1-18.
Faskalia., wibowo M. agus. (2014). Skrining fitokimia, uji aktivitas antioksidan dan uji sitotoksik ekstrak methanol pada akar dan kulit batang soma. Jkk 3(3) : 1-6.
Sastrawan idza N, Sangi meiske, Kamu Vanda. (2013). Skrining Fitokimia dan uji aktivitas antioksidan biji adas (foeniculum Vulgare) menggunakan metode DPPH, Jurnal ilmiah sains. 13(2) : 111-114.
Nigsih Surya, paturusi Andi Armisman Edi, K. amalia Nur Rezki. (2015). Uji Efek Penyembuh Gel Ekstrak daun jarak Merah (Jatropha gossypifolia Linn) terhadap Luka Sayat pada kelinci 3(3) : 104-110
Mappa T., Edi hosea jaya., Kojong Novel. (2013). Formulasi Gel Ekstrak daun saladahan (Peperomia Pellucia (L) H.B.K) dan uji efektivitas nya Terhadap Luka bakar Pada Kelinci (oryctologus cuniculus). Jurnal Ilmiah Farmasi 2(2) : 2302-2493.
Maulina Lena., Sugihartini Nining. (2015). Formulasi Gel Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana L.) dengan variasi gelling agent sebagai sediaan luka bakar. Pharmaciana 5(1) : 43-52
Supomo dan Sapri komalasari Astri Nur. (2016). Formulasi Gel Oksidan Ekstrak Kulit Buah Manggis (Garciana Mangostana L) dengan basis Carbopol, Jurnal Ilmiah Ibnu sina 1(1) : 50-60.
Rosyidah Hilmatul. (2016). Standarisasi Ekstrak etil asetat Anting-anting (Acalyphaudica Linn) sebagai herba Antimalaria. Skripsi. Fakultas Sains dan teknologi universitas islam negri.
Widayanti Ari., Fauzan Desti Astri Ayu., & R Nanik Setiadi. (2016). Formulasi sediaan Gel Kolagen Ikan Tuna (Thunus Albacares) dengan Hidroksilpropil metil selulosa (HPMC) sebagai Gelling Agent, Farmasiana 3(1) : 1-6.
Downloads
Issue
Section
License
I. ORIGINALITY, AUTHORSHIP, AND COPYRIGHT
The manuscripts submitted for publication must be research works written in English that have not been previously published and  are not being considered for publication elsewhere. All the authors must have agreed to the submission and to the order of their names on the title page. They must also have agreed that the corresponding author may act on their behalf throughout the editorial review and publication process. The corresponding author is responsible for obtaining such agreement.
Requests for changes in authorship (order of listing or addition or deletion of names) after submission should be accompanied by signed statements of agreement from all the parties involved. To maintain and protect the publisher‘s ownership and rights and to protect the original authors from misappropriations of their published work, author(s) are required to sign a Journal Publishing Agreement and send it to the editorial office (jhtm@uui.ac.id).
II. PERMISSION
The author is responsible for acquiring the permission(s) to reproduce any copyrighted figures, tables, data, or text that are being used in the submitted paper. Authors should note that text quotations of more than 250 words from a published or copyrighted work will require grant of permission from the original publisher to reprint. The written permission letter(s) must be submitted together with the manuscript.
III. EDITORIAL REVIEW AND REVISION
All papers will be critically read by at least two anonymous reviewers, selected for their competence in the subject area of the paper. Acceptance of the paper will depend upon its scientific merit and suitability for the journal. A paper may be accepted in its original form or subject to revision.
The reviewers' (and editor's) suggestions will be conveyed to the author, who will then have an opportunity to revise the paper. A manuscript returned to an author for revision can be held for a maximum of eight weeks.
The accepted paper will be edited by native English speakers. The cost of language editing service is currently free.
IV. PROOFS
Galley proofs (PDF format) for an accepted article will be sent by e-mail to the corresponding author for copyediting corrections. The core content of an article cannot be changed at this time. It is the author's responsibility to check the entire manuscript, including tables, figure legends, and cited reference numbers, not just the items queried. The proofs should be corrected and mailed to the editorial office within 48 hours of receipt in order to expedite publication. Only one set of corrections will be accepted. In other words, it is important to ensure that all of your corrections are sent to us in one communication.
V. Â REPRINTS
Five free reprint copies of the published article will be shipped to the corresponding authors in Indonesia only, approximately two weeks after the issue is printed. Authors, including overseas authors, who wish to purchase reprints, are required to complete the Reprint Order Form, which will be sent with the galley proofs to corresponding authors. This form must be returned together with the corrected galley proofs.
