Aktivitas Hepatoprotektif Ekstrak Umbi Bit (Beta vulgaris L.) pada Histologi Hepar Mencit yang diinduksi Parasetamol
DOI:
https://doi.org/10.33143/jhtm.v8i1.1989Abstract
Penelitian ini bertujuan untuk mengetahui aktivitas hepatoprotektif dari ekstrak etanol umbi bit pada histologi hepar mencit yang diinduksi paracetamol. Metode penelitian dilakukan secara eksperimental laboratorium. Mencit diberikan ekstrak etanol umbi bit dosis 500 mg/kg BB (P1), ekstrak etanol umbi bit dosis 300 mg/kg BB (P2), ekstrak etanol umbi bit dosis 100 mg/kg BB (P3), kontrol positif digunakan Curcuma® dan kontrol negatif digunakan Na CMC 0,5%. Perlakuan diberikan selama 7 hari berturut-turut. Pada hari ke-8 mencit diinduksi parasetamol dosis toksik selama 3 hari. Pada hari ke-10 dilakukan pembedahan untuk diambil hepar mencit. Hasil penelitian ini menunjukkan bahwa perlakuan dengan pemberian ekstrak etanol umbi bit dengan dosis 500 mg/kg BB, 300 mg/kg BB, dan 100 mg/kg BB dapat memberikan efek hepatoprotektif terhadap gambaran histopatologi hepar. Pada penelitian ini dapat disimpulkan umbi bit mempunyai efektivitas hepatoprotektor.
Kata kunci : Umbi Bit, Hepatoprotektif, hepar
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