PENGARUH EFEK EKSTRAK UMBI BIT (Beta Vulgaris L.) DALAM MENGHAMBAT PENINGKATAN KADAR ASPARTATE AMINOTRANSFERASE (AST) DAN ALANIN AMINOTRANSFERASE (ALT) PADA MENCIT JANTAN
DOI:
https://doi.org/10.33143/jhtm.v10i1.4189Abstract
Umbi bit (Beta Vulgaris L.) secara tradisional telah digunakan untuk berbagai penyakit salah satunya yaitu untuk menurunkan kadar Aspartate Aminotransferase (AST) dan Alanin Aminotransferase (ALT) sebagai zat aditif hepatoprotektor. Adapun tujuan dari penelitian ini yaitu untuk mengetahui dosis yang efektif untuk mencapai efek penurunan kadar Aspartate Aminotransferase (AST) dan Alanin Aminotransferase (ALT) pada mencit (Mus musculus L.). Metode yang digunakan adalah eksperimental laboratorium dengan memvariasikan suspensi ekstrak umbi bit 100 mg/kgBB, 300 mg/kgBB dan 500 mg/kgBB serta curcuma sebagai kontrol positif dan Na-CMC sebagai kontrol negatif. Hasil penelitian menunjukkan bahwa ekstrak umbi bit memiliki aktivitas hepatoprotektor dengan suspensi ekstrak umbi bit 100 mg/kgBB, suspensi ekstrak umbi bit 300 mg/kgBB dan suspensi ekstrak umbi bit 500 mg/kgBB berturut pada kadar Aspartate Aminotransferase (AST) diperoleh 245 U/L, 191 U/L dan 186 U/L sedangkan pada kontrol positif (curcuma) 166 U/L. Selanjutnya pada kadar Alanin Aminotransferase (ALT) diperoleh 65 U/L, 57 U/L dan 49 U/L sedangkan pada kontrol positif (curcuma) 43 U/L. Data hasil penelitian dianalisis dengan program SPSS yang di analisis menggunakan uji ANOVA (Analysis Of Varian) didapatkan nilai P Value (<0,05). Berdasarkan penghujian post hoc menunjukkan suspensi ekstrak umbi bit yang relatif sama dengan curcuma (kontrol positif) terhadap penurunan kadar Aspartate Aminotransferase (AST) yaitu suspensi ekstrak umbi bit 300 mg/kgBB. Sedangkan pada penurunan kadar Alanin Aminotransferase (ALT) ialah suspensi ekstrak umbi bit 500 mg/kgBB. Disarankan kepada pembaca untuk dapat lebih memanfaatkan umbi bit sebagai obat terapi hepatoprotektor.
Kata kunci : Umbi bit (Beta Vulgaris L.), hepatoprotektor. Aspartate Aminotransferase dan Alanin Aminotransferase.
Beetroot (Beta Vulgaris L.) has traditionally been used for various diseases, one of which is to reduce Aspartate Aminotransferase (AST) and Alanin Aminotransferase (ALT) levels as a hepatoprotector additive. The objectives of this research are to determine the effective dose to achieve the effect of reducing Aspartate Aminotransferase (AST) and Alanin Aminotransferase (ALT) levels in mice (Mus musculus L.). The method used is laboratory experiment by varying the suspension of beetroot extract 100 mg / kgBB, 300 mg / kgBB and 500 mg / kgBB and curcuma as positive control and Na-CMC as negative control. Research results shows that beetroot extract has hepatoprotector activity with beetroot extract suspension of 100 mg/kgBB, beetroot extract suspension of 300 mg/kgBB and beetroot extract suspension of 500 mg/kgBB respectively at Aspartate Aminotransferase (AST) levels obtained 245 U/L, 191 U/L and 186 U/L while in positive control (curcuma) 166 U/L. Furthermore, Alanin Aminotransferase (ALT) levels were obtained 65 U/L, 57 U/L and 49 U/L while in the positive control (curcuma) 43 U/L. The data from the study were analysed with the SPSS program using the ANOVA (Analysis of Variance) test which obtained a P value (<0.05). Based on post hoc testing, the suspension of beetroot extract which is relatively the same as curcuma (positive control) to reduce Aspartate Aminotransferase (AST) levels is a suspension of beetroot extract 300 mg/kgBB. While the decrease in Alanin Aminotransferase (ALT) levels is a suspension of beetroot extract 500 mg / kgBB. It is recommended to readers to be able to make more use of beetroot as a hepatoprotector therapy drug.Â
Keywords : Beetroot (Beta Vulgaris L.), hepatoprotector. Aspartate Aminotransferase and Alanine Aminotransferase.
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