FORMULASI DAN EVALUASI SEDIAAN TRANSDERMAL PATCH DARI EKSTRAK ETANOL BUAH PALA (MYRISTICA FRAGRANS HOUTT.) SEBAGAI PEREDA NYERI
DOI:
https://doi.org/10.33143/jhtm.v11i1.4839Keywords:
Rhematoid arthritis, buah pala, transdermal patch, analgesik.Abstract
Buah pala merupakan tanaman obat tradisional yang telah lama digunakan. Buah pala memiliki aktivitas sebagai analgesik karena mengandung senyawa flavonoid. Senyawa flavonoid memiliki peran dalam menghambat pembentukan prostaglandin. Rhematoid arthitis merupakan penyakit sendi yang menyebabkan nyeri, menurut WHO penderita penyakit ini telah mencapai 355 juta jiwa dengan penghantaran obat yang dapat mengiritasi lambung, sehingga diberikan alternatif lain dengan penghantaran obat secara transdermal untuk mengurangi first pass effect. Penelitian ini dilakukan untuk memformulasi ekstrak etanol buah pala menjadi sediaan transdermal patch sebagai pereda nyeri. Penelitian dilakukan secara eksperimen laboratorium, ekstrak yang didapat diformulasikan menjadi sediaan patch selanjutnya dilakukan uji evaluasi dan uji efektivitas analgesik. Analisa data dilakukan secara statistik dengan One Way ANOVA. Hasil penelitian menunjukkan bahwa ekstrak etanol buah pala dapat diformulasikan menjadi sediaan transdermal patch yang memiliki efektivitas sebagai pereda nyeri dengan hasil pengujian terhadap hewan coba yaitu mencit yang telah dianalisis secara statistik sehingga diperoleh formulasi F1(10%), F2 (15%), dan F3(20%) memiliki perbedaan efektivitas sebagai pereda nyeri. Formulasi terbaik yaitu formula 3 dengan konsentrasi 20% dengan nilai p-value yaitu 0.000 atau <0.05.
References
Julianti, T.R., Mardianingrum, R. and Adlina, S. (2024) ‘Potensi Ekstrak Rimpang Kencur (Kaempferia Galanga L.) Dalam Sediaan Transdermal Patch Sebagai Antiinflamasi’, Perjuangan Nature Pharmaceutical Conference, 1(1), pp. 47–63.
Kharisma, K. P., Wahyuni, D., Hesturini, R. J., & Lestari, A. D. (2020). Uji Aktivitas Analgesik Daun Trembesi (Samanea saman (Jacq.) Merr.). Jurnal Wiyata, 7(2), 138–146.
Lara, Audrey Dhinda, Elisma and Sani K, F. (2023) ‘Investigating the Analgesic Activity of Jeruju Leaf Infusion (Acanthus Ilicifolius L.) on Male White Mice (Mus Musculus)’, International Journal of Prevention Practice and Research, 03(01), pp. 01–05.
Meilina, R., Maghlisa, U.I. and Dhirah, U.H. (2022) ‘Antiinflamasi Ekstrak Etanol Bunga Kenop (Gomphrena globosa L.) pada Tikus (Rattus novergicus)’, Journal of Healthcare …, 8(2), pp. 648–657. Available at: http://www.jurnal.uui.ac.id/index.php/JHTM/article/view/2337%0Ahttp:// www.jurnal.uui.ac.id/index.php/JHTM/article/viewFile/2337/1197.
Nabila Nur Latifa, Lanny Mulqie, & Siti Hazar. (2022). Penetapan Kadar Sari Larut Air dan Kadar Sari Larut Etanol Simplisia Buah Tin (Ficus carica L.). Bandung Conference Series: Pharmacy, 2(2). https://doi.org/10.29313/bcsp.v2i2.4575
Nur, A., Fiskia, E. and Rahman, I. (2022) ‘Aktivitas Antiinflamasi Daging Buah Pala (Myristica fragrans Houtt.) Pada Tikus Putih Yang Diinduksi Karageenan’, JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X, 14(1), pp. 10–16.
Available at: https://doi.org/10.35617/jfionline.v14i1.87.
Nur, A. and Rahman, I. (2020). Uji Efek Analgetik Ekstrak Etanol Buah Pala Terhadap Tikus Putih Analgetic Effects Test Of Pala Fruit Ethanol Extract Against White Rats’, 2(2), pp. 268–5912.
Rosalia Agaus, L. and Vinalia Agaus, R. (2019) ‘Manfaat Kesehatan Tanaman Pala (Myristica fragrans)’, Medula, 6, pp. 662–666.
Sandi, Wardoyo, A.V. and Zakiah Oktarlina, R. (2019) ‘Literature Review Tingkat Pengetahuan Masyarakat Terhadap Obat Analgesik Pada Swamedikasi Untuk Mengatasi Nyeri Akut’, Association Between the Level of Public Knowledge Regarding Analgesic Drugs And Self-Medication in Acute Pain, 10(2), pp. 156–160. Available at: https://doi.org/10.35816/jiskh.v10i2.138.
Sianturi, S., & Rachmatiah, T. (2020). Potensi Analgesik Ekstrak Etanol Daun Senduduk (Melastoma malabathricum Linn.) pada Mencit Jantan (Mus
musculus L.) dengan Metode Rangsang Panas. Journal of Science and Technology, 1(1), 39–48
Sirait, S.M. and Enriyani, R. (2021) ‘Skrining Fitokimia dan Pengaruh Cara Pengeringan Terhadap Kualitas Ekstrak Etanol Daging Buah Pala (Myristica fragrans Houtt)’, Warta Akab, 45(2), pp. 1–5.
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