AKTIVITAS PENYEMBUHAN LUKA SALEP EKSTRAK BIJI KETUMBAR (CORIANDRUM SATIVUM L.) PADA MENCIT (MUS MUSCULUS L.) YANG TERINFEKSI STAPHYLOCOCCUS AUREUS
DOI:
https://doi.org/10.33143/jhtm.v7i2.1990Abstrak
Penelitian ini bertujuan untuk mengetahui aktivitas penyembuhan luka dari salep ekstrak biji ketumbar pada mencit yang terinfeksi bakteri Staphyloccus aureus. Metode yang digunakan pada penelitian ini adalah metode eksperimental. Salep ekstrak biji ketumbar dibuat dalam 3 formulasi yaitu F1 (formulasi salep mengandung sebanyak 4 gram ekstrak etanol ketumbar), F2 (formulasi salep mengandung sebanyak 6 gram ekstrak etanol ketumbar), F3 (formulasi salep mengandung sebanyak 8 gram ekstrak etanol ketumbar). Sebagai kontrol negatif adalah dasar salep tanpa kandungan ekstrak biji ketumbat dan sebagai control positif ada lah salep hidrokartison. Hasil penelitian menunjukkan bahwa penyembuhan luka sayat pada mencit menggunakan salep dengan formulasi sebanyak 8 gram ekstrak etanol ketumbar memberikan hasil yang efektif terhadap penyembuhan luka sayat pada mencit dibandingkan dengan salep dengan formulasi FI dan FII. Kesimpulan penelitian ini bahwa sediaan salep ekstrak biji ketumbar memiliki aktivitas yang baik terhadap penyembuhan luka sayat pada mencit yang terinfeksi bakteri Staphlococcus aureus.
Kata kunci: biji ketumbar, sediaan salep, luka sayat, mencit
This study aims to determine the wound healing activity of coriander seed extract ointment in mice infected with Staphyloccus aureus bacteria. The method used in this study is experimental. Coriandrum sativum seed extract ointment is made in 3 formulations. F1 (ointment formulation contains as much as 4 grams of coriandrum sativum ethanol extract), F2 (ointment formulation contains as much as 6 grams of coriandrum sativum ethanol extract), F3 (ointment formulation contains as much as 8 grams of coriandrum sativum ethanol extract). As a negative control is the basis of ointment without the content of coriandrum sativum seed extract and as a positive control there is hydroartison ointment. The results showed that the healing of my sores on mice using ointments with formulations of as much as 8 grams of coriandrum sativum ethanol extract provided effective results against the healing of my sores on mice compared to ointments with FI and FII formulations. The conclusion of this study is that the preparation of coriandrum sativum seed extract ointment has good activity against the healing of sores in mice infected with staphlococcus aureus bacteria.
Keywords: Coriandrum sativum, Staphylococcus aureus, ointment
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