INKOMPATIBILITAS INJEKSI DEXAMETHASONE DENGAN BEBERAPA LARUTAN INTRAVENA
DOI:
https://doi.org/10.33143/jhtm.v12i1.4998Kata Kunci:
Dexamethasone sodium phosphate, inkompatibilitas, larutan intravena, injeksi bolus, stabilitas fisik.Abstrak
Penggunaan injeksi dexamethasone sodium phosphate secara intravena merupakan terapi yang umum dalam pengobatan berbagai kondisi inflamasi dan imunologis. Namun, pencampuran injeksi ini dengan larutan intravena lain seperti NaCl 0,9%, Dextrose 10%, dan Ciprofloxacin dapat menimbulkan risiko inkompatibilitas fisik dan kimia yang membahayakan pasien. Penelitian ini bertujuan untuk mengevaluasi kompatibilitas pencampuran injeksi dexamethasone dengan ketiga larutan tersebut melalui dua metode: pencampuran dalam satu wadah dan penyuntikan bolus menggunakan infus set. Evaluasi dilakukan berdasarkan parameter warna dan kekeruhan secara visual, pH, ukuran dan morfologi partikel menggunakan mikroskop digital. Hasil yang diharapkan dari penelitian ini adalah identifikasi potensi inkompatibilitas yang dapat muncul akibat interaksi antar sediaan injeksi dan larutan infus, serta memberikan rekomendasi praktis dalam pengelolaan pemberian obat secara intravena di fasilitas pelayanan kesehatan. Penelitian ini berkontribusi pada praktik farmasi klinik yang lebih aman dan rasional.
The intravenous use of dexamethasone sodium phosphate injection is a common therapy in the treatment of various inflammatory and immunologic conditions. However, mixing this injection with other intravenous solutions such as NaCl 0.9%, Dextrose 10%, and Ciprofloxacin may pose a risk of physical and chemical incompatibility that endangers patients. This study aimed to evaluate the compatibility of mixing dexamethasone injection with these three solutions through two methods: mixing in one container and bolus injection using an infusion set. The evaluation was based on visual color and turbidity parameters, pH, particle size and morphology using digital microscopy. The expected results of this study are the identification of potential incompatibilities that can arise due to interactions between injection preparations and infusion solutions, and provide practical recommendations in the management of intravenous drug administration in health care facilities. This research contributes to safer and more rational clinical pharmacy practice.
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