Degenerasi Dan Nekrosis Pada Hati Mencit Diabetes yang Diberi Ekstrak Kulit Buah Rambai (Baccaurea motleyana Muell. Arg)
DOI:
https://doi.org/10.33143/jhtm.v4i1.172Abstract
Diabetes melitus (DM) merupakan penyakit gangguan metabolik menahun akibat penurunan fungsi pankreas. Salah satu bagian tumbuhan yang diketahui unutk menurunkan kadar gula darah yaitu kulit buah rambai. Tujuan penelitian ini untuk mengetahui keamanan dalam penggunaan tumbuhan sebagai obat herbal agar tidak menimbulkan efek berbahaya yang tidak diinginkan, maka perlu dilakukan uji toksisitas pada hati mencit dengan mengamati degenerasi dan nekrosis. Rancangan penelitian yang digunakan dalam penelitian ini ialah Rancangan Acak Lengkap (RAL) dengan 6 perlakuan dan 4 ulangan. Perlakuan terdiri kontrol negatif (akuades), kontrol positif (Glibenklamid), dan ekstrak etanol kulit buah rambai dengan dosis bertingkat 200 mg/kgBB, 400 mg/kgBB, 800 mg/kgBB, 1600 mg/kgBB yang diberikan secara oral. Data dianalisis menggunakan analisis varians (ANAVA) dan apabila perlakuan berpengaruh maka diuji lanjut menggunakan uji jarak berganda Duncan dengan taraf kepercayaan 5%. Hasil pengamatan menunjukkan pemberian ekstrak etanol kulit buah rambai berpengaruh nyata terhadap kerusakan pada sel-sel hati mencit diabetes. Kerusakan yang disebabkan degenerasi dan nekrosis pada sel hati. Dosis aman ekstrak etanol kulit buah rambai ialah 1600 mg/kg BB yang dapat dijadikan obat antidiabetes dikarenakan rerata sel degenerasi dan nekrosis sel hati lebih rendah dibandingkan kontrol positif (glibenklamid).
Kata Kunci:Â Diabetes melitus, Baccaurea motleyana, hati, degenerasi, nekrosisÂ
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