Uji Efek Antipiretik Infusa Daun Kedondong (Spondias dulcis Parkinson) Pada Mencit (Mus musculus)
DOI:
https://doi.org/10.33143/jhtm.v6i2.1931Abstract
Salah satu jenis tumbuhan yang dapat berpotensi sebagai tanaman obat adalah daun kedondong (Spondias dulcis), salah satu manfaat daun kedondong ialah mengobati demam, hal ini disebabkan daun kedondong (Spondias dulcis) mengandung flavonoid, tanin, saponin, dan alkaloid. Tujuan penelitian adalah Untuk mengetahui efek antipiretik infusa daun kedondong pada mencit. Penelitian ini menggunakan pendekatan kuantitatif yang menghasilkan data yang berupa angka. Rancangan penelitian yang digunakan ialah Rancangan Acak Lengkap (RAL). Penelitian ini terdiri dari 5 perlakuan dan 5 ulangan yaitu kontrol positif (Paracetamol), kontrol negatif (akuades), daun kedondong dosis rendah (5 lembar), daun kedondong dosis sedang (10 lembar), daun kedondong dosis tinggi (15 lembar). Data yang diperoleh disajikan dalam bentuk tabel sederhana dan diuji statistik parametrik, yaitu ANOVA (Analysis of Varian). Apabila terdapat pengaruh perlakuan infusa daun kedondong terhadap suhu tubuh maka akan dilanjutkan dengan uji lanjut Duncan dengan taraf kepercayaan 95%. Hasil penelitian infusa daun kedondong mempunyai efek antipiretik yang dapat menurunkan suhu tubuh mencit. Perlakuan infusa 10 lembar daun kedondong menunjukkan penurunan suhu tubuh mencit terbaik setelah diberikan 30 menit pertama. Dosis infusa daun kedondong (Spondias dulcis Parkinson) yang paling efektif dapat menurunkan suhu tubuh adalah dosis 10 lembar.
Kata Kunci : Daun Kedondong, Infusa, Pepton, Suhu tubuh.
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