Antiinflamasi Ekstrak Etanol Bunga Kenop (Gomphrena globosa L.) pada Tikus (Rattus novergicus)
DOI:
https://doi.org/10.33143/jhtm.v8i2.2337Abstract
Tujuan dari penelitian ini adalah untuk mengevaluasi potensi aktivitas anti-inflamasi ekstrak etanol dari daun kenop dengan analisis hasil skrining fitokimia. Dua puluh ekor tikus wistar dibagi menjadi 5 kelompok yang terdiri dari 5 hewan. Pengujian anti-inflamasi dilakukan dengan mengukur persentase peradangan pada tikus, setelah pemberian ektrak etanol bunga kenop (40 mg/BB, 80 mg/BB dan 160 mg/BB) sebelumnya diinduksi oleh karagenan. Hasil penelitian menunjukkan ekstrak bunga kenop dosis 160 mg/BB memiliki potensi antiinflamasi sebesar 30% yang mendekati Na-Diklofenak didapatkan persentase rata-rata 38%. Kesimpulan: ektrak etanol bunga kenop ini memiliki aktivitas anti-inflamasi.
Kata kunci : Bunga kenop, Na-Diklofenak dan antiinflamasi.
The study aimed to evaluate the potential anti-inflammatory activities of ethanol extract of Gomphrena globosa, related to a phytochemical screening analysis. twenty-five Wistar rats were divided into 5 groups of 5 animals. An anti-inflammatory test was carried out by measuring the percentage of inflammation in rats, after the administration of 1 ethanol extract of Gomphrena globosa, which was previously induced by the carrageenan. The doses of extract of Gomphrena globosa160 mg/BB had anti-inflammatory activity compared to 30% is Na-Diclofenac had anti-inflammatory activity compared to 38%. Conclusion: extract of Gomphrena globosa compound had an anti-inflammatory activity.
Keywords: Gomphrena globosa L, Na-Diklofenak and anti-inflammatory.
References
Arthi, V., & Prasanna, G. (2016). Hptlc Finger Print Profile And In Vitro Antioxidant Activity Of Gomphrena Globosa L. Flowers. International Journal Of Pharmaceutical Sciences Review And Research, 39(1), 208–215.
Azmat, U. E., Sirisha, M., & Safiya, B. (2020). GC-MS Analysis Of Bioactive Compounds And Phytochemical Evaluation Of. Journal Of Drug Delivery & Therapeutics, 10(2), 53–58.
Maghfirah, H., Lestari, S., & Meilina, R. (2018). Formulasi Balsam Aromatherapy Dari Ekstrak Minyak Atsiri Daun Sembung ( Blumea Balsamifera L .) Formulation Of Aromatherapy Balsam From Essential Oil ( Blumea Balsamifera L .). 4(1), 88–94.
Maria, U. (2016). Formulasi Gel Ekstrak Daun Kelor ( Moringa Oleifera Lam .) Sebagai Anti Inflamasi Topikal Pada Tikus ( Rattus Novergicus ). Journal Of Pharmacetical And Medicial Sciences, 1(2), 30–35.
Meilina, R. (2017). Efek relaksasi ekstrak dan fraksi daun belimbing wuluh ( averrhoa bilimbi l .) Terhadap kontraksi otot polos ileum tikus terisolasi oleh : rulia meilina program studi magister farmasi efek relaksasi ekstrak dan fraksi daun belimbing wuluh ( averrhoa bilim.
Meilina, R., & Afriana, s. (2019). Efek antiinflamsi gel kacang hijau pada mencit putih ( mus musculus ) essence to keep body healthy because it not only contains rich protein but also has the other. 5(2), 231–238.
Meilina, R., Dewi, R., & Nadia, P. (2020). Sosialisasi Pemanfaatan Tanaman Obat Keluarga ( Toga ) Untuk Meningkatkan Imun Tubuh Di Masa Pandemi Covid-19 Socialization Of The Utilization Of Medicinal Plants To Improve Body Immune In The Pandemic Covid-19. 2(2), 89–94.
Meilina, R., & Japnur, I. S. (2020). Aktivitas Antioksidan Formulasi Sediaan Sabun Cair Dari Buah Apel ( Malus Domesticus ) Antioxidant Activities For Liquid Soap Formulation From Apple Fruit ( Malus Domesticus ). 6(1), 404–410.
Meilina, R., & Mukhtar, R. (2018). Efek Antiinflamasi Ekstrak Etanol Rimpang Kunyit ( Curcuma Domestica Val .) Pada Tikus Putih Yang Diinduksi Karagenan Antiinflammatory Effects Of Ethanol Extract Of Curcuma Domestica Val . On Carrageenan-Induced White Mice. 4(1), 111–117.
Nufus, N., Ramadhani, D., Nurman, S., & Meilina, R. (2018). Formulasi Lotion Ekstrak Air Daun Tahi Ayam ( Tageteserecta L .) Sebagai Repellent Nyamuk Formulation Lotion As Repellent Mosquito Using Water Extract Of Tagetes Erecta ( L .). 4(1), 95–102.
Nurjanah, F., & Sumiwi, S. A. (2013). Review Artikel: Aktivitas Antiinflamasi Berbagai Tumbuhan Yang Diinduksi Oleh Karagenan. Farmaka, 17(1), 1–15.
P, n.-h., & karagenan, y. D. (2017). Uji aktivitas antiinflamasi senyawa sinamamida secara in-vivo uji aktivitas antiinflamasi senyawa n , n- bis- ( hidroksietil ) - p -metoksi sinamamida secara in-vivo.
Pramitaningastuti, A. S. (2017). Uji Efektivitas Antiinflamasi Ekstrak Etanol Daun Srikaya (Annona Squamosa. L) Terhadap Udema Kaki Tikus Putih Jantan Galur Wistar. Jurnal Ilmiah Farmasi, 13(1), 8–13.
Sulistyawati, R., & Pratiwi, P. Y. (2015). Pengaruh Pemberian Ekstrak Etanol Daun Kelor ( Moringa Oleifera L .) Terhadap Aktivitas Analgesik Dan Antiinflamasi Melalui Ekspresi Enzim Siklooksigenase Analgesic And Antiinflammatory Activity Of Ethanol Extract Of Kelor Leaves ( Moringa Oleifera L .) T. 31–38.
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