PENGARUH EKSTRAK DAUN JAMBLANG (Syzygium cumini L.) UNTUK MENURUNKAN KADAR GLUKOSA DARAH MENCIT (Mus musculus) YANG DIINDUKSI GLUKOSA
DOI:
https://doi.org/10.33143/jhtm.v10i1.4187Abstract
Gula darah atau glukosa darah merupakan sejumlah kandungan kadar gula yang berada dalam sirkulasi darah pada tubuh. Peningkatan kadar gula darah secara berlebihan dapat menimbulkan gangguan kesehatan. Peningkatan kadar glukosa darah yang disebabkan oleh pola makan yang kurang sehat, selain itu penyakit ini juga diakibatkan karena faktor genetik. Tumbuhan jamblang merupakan tumbuhan yang berpotensi sebagai obat tradisional dalam menurunkan kadar glukosa. Karena tumbuhan tersebut mengandung senyawa alkaloid, flavonoid, tanin, saponin dan glukosida yang berpotensi sebagai antidiabetes. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak daun jamblang dan dosis minimum dalam menurunkan kadar glukosa. Metode penelitian ini eksperimental laboratorium. Hasil penelitian menggunakan uji One Way Anova diperoleh nilai signifikan pada hari ke 0 sebesar 0,985, hari ke 7 sebesar 0,862, hari ke 9 sebesar 0,000, hari ke 12 sebesar 0,000 dan hari ke 15 sebesar 0,000. Dari hasil penelitian menunjukkan ekstrak daun jamblang mampu menurunkan kadar glukosa mencit. Pemberian ekstrak daun jamblang menunjukkan penurunan kadar glukosa sejak hari ke 9 hingga hari ke 15. Ekstrak daun jamblang berpengaruh secara signifikan terhadap penurunan kadar gula darah mencit. Kesimpulan Pemberian ekstrak daun jamblang dapat menurunkan kadar gula darah sebesar 66% dengan dosis minimum yaitu 100 mg/kg BB.
Blood sugar or blood glucose is a number of sugar levels in the blood circulation in the body. Excessive increases in blood sugar levels can cause health problems. Increased blood glucose levels are caused by unhealthy eating patterns, besides this disease is also caused by genetic factors. The jamblang plant is a plant that has potential as a traditional medicine for lowering glucose levels. Because these plants contain alkaloids, flavonoids, tannins, saponins and glucosides which have the potential to be anti-diabetic This study aims to determine the effect of administering jamblang leaf extract and the minimum dose in reducing glucose levels. This research method is laboratory experimental. The research results showed that the results of the One Way Anova test obtained a significant value on day 0 of 0.985, day 7 of 0.862, day 9 of 0.000, day 12 of 0.000 and day 15 of 0.000. The research results show that jamblang leaf extract is able to reduce glucose levels in mice. Administration of jamblang leaf extract showed a decrease in glucose levels from day 9 to day 15. Jamblang leaf extract had a significant effect on reducing blood sugar levels in mice. The conclusion is that the Administration of jamblang leaf extract can reduce blood sugar levels by 66% with a minimum dose of 100 mg/kg BB.
Keywords : Blood Sugar, Antidiabetic, Jamblang Leaf, Metformin
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