EFEK ANTIINFLAMSI GEL KACANG HIJAU PADA MENCIT PUTIH (Mus musculus)
DOI:
https://doi.org/10.33143/jhtm.v5i2.422Abstract
Abstrak
Â
Kacang hijau sebagai bahan makanan manusia cukup baik dikonsumsi untuk memenuhi kebutuhan gizi dan kesehatan tubuh, karena di samping kaya protein, juga mengandung zat-zat gizi lainnya yang cukup lengkap. Penelitian mengenai kacang hijau sebelumnya menyatakan bahwa kacang hijau mengandung senyawa metabolit sekunder diantaranya, flavonoid, tanin, steroid/triterpenoid, dan saponin yang berpotensi sebagai antioksidan. Metode yang digunakan dalam penelitian ini ialah metode eksperimental, meliputi pengumpulan tumbuhan, pengolahan dan pengujian sampel, pembuatan dan pengujian sediaan terhadap hewan coba sampai dengan analisis data statistik. Hasil persentase perhitungan dari pengurangan perubahan diameter pada luka sayat diperoleh efektivitas penyembuhan luka yang sangat baik pada betadin salep sebagai kontrol positif, sediaan gel ekstrak 10%, ekstrak 7.5% dan tanpa ekstrak (kontrol negatif), dan ekstrak 5%. Penyembuhan luka di mulai pada hari ke- 8 sampai ke-21 untuk kontrol gel ekstrak 10%. Penyembuhan luka pada hari ke-13 sampai ke-23 untuk gel ekstrak 7.5% dan tanpa ekstrak. Penyembuhan luka pada hari ke-13 sampai ke-24 untuk betadin salep. Penyembuhan luka pada hari ke-13 sampai ke-25 untuk gel ekstrak 5%. Berdasarkan hasil pengamatan selama penelitian hewan uji, bahwa pada ekstrak 10% lebih cepat mengalami masa penyembuhan dibanding dengan sampel pembanding yaitu betadin salep sebagai kontrol positif.
References
Ardana, M., Aeyni, V., & Ibrahim, A. (2015). Formulasi dan optimasi basis gel HPMC (Hidroxy Propyl Methyl Cellulose) dengan berbagai variasi kosentrasi . J. Trop. Pharm. Chem. Vol 3 (2).
Fauziah, S. R., Wangi TW, M. A., & Sulastri, I. (2017). Uji efektivitas anti-inflamasi salep ekstrak rimpang kencur(Kaempferia galanga L.) terhadap luka sayat pada tikus jantan. Jurnal Sains dan Ilmu Farmasi. Vol. 2 (3).
Fajrina, A. (2017). Formulasi sediaan gel ekstrak etanol daun Jambu bol (Syzgium malaccense L. Merr & Perry) Sebagai pengobatan luka sayat. Skripsi. Sumatera Utara: Universitas Sumatera Utara.
Mayasari, U., Laoli, M. T. (2018). Karakterisasi simplisia dan skrining fitokimia daun jeruk lemon (Citrus lemon (L.) Burn.f). Klorofil. Vol.2 (1).
Moniharapon, P. J., Queljoe, E. D., & Simbala, H. (2016). Identifikasi fitokimia dan uji aktivitas antioksidan ekstrak etanol tauge (Phaseolus radiatus L.). Jurnal Ilmiah Farmasi – UNSRAT . Vol. 5 (4).
Ningsih, S., Patusuri, A. A., & Amalia, K. N. R. (2015). Uji efek penyembuhan gel ekstrak daun jarak merah (Jatropha gossypifolia Linn.) terhadap luka sayat pada kelinci (Oryctolagus cuniculus). JF FIK UINAM. Vol.3 (3).
Novidiyanto, Farmawati, A., & Lestari, L. A. (2016). Pengaruh pemberian kecambah kacang hijau (Phaseolus radiatus L.) terhadap kadar malondealdehid (MDA) plasma dan jaringan hati tikus Sprague Dawley yang diberi pakan lemak tinggi. Jurnal Gizi Klinik Indonesia, Vol 13 (2).
Downloads
Published
Issue
Section
License
I. ORIGINALITY, AUTHORSHIP, AND COPYRIGHT
The manuscripts submitted for publication must be research works written in English that have not been previously published and  are not being considered for publication elsewhere. All the authors must have agreed to the submission and to the order of their names on the title page. They must also have agreed that the corresponding author may act on their behalf throughout the editorial review and publication process. The corresponding author is responsible for obtaining such agreement.
Requests for changes in authorship (order of listing or addition or deletion of names) after submission should be accompanied by signed statements of agreement from all the parties involved. To maintain and protect the publisher‘s ownership and rights and to protect the original authors from misappropriations of their published work, author(s) are required to sign a Journal Publishing Agreement and send it to the editorial office (jhtm@uui.ac.id).
II. PERMISSION
The author is responsible for acquiring the permission(s) to reproduce any copyrighted figures, tables, data, or text that are being used in the submitted paper. Authors should note that text quotations of more than 250 words from a published or copyrighted work will require grant of permission from the original publisher to reprint. The written permission letter(s) must be submitted together with the manuscript.
III. EDITORIAL REVIEW AND REVISION
All papers will be critically read by at least two anonymous reviewers, selected for their competence in the subject area of the paper. Acceptance of the paper will depend upon its scientific merit and suitability for the journal. A paper may be accepted in its original form or subject to revision.
The reviewers' (and editor's) suggestions will be conveyed to the author, who will then have an opportunity to revise the paper. A manuscript returned to an author for revision can be held for a maximum of eight weeks.
The accepted paper will be edited by native English speakers. The cost of language editing service is currently free.
IV. PROOFS
Galley proofs (PDF format) for an accepted article will be sent by e-mail to the corresponding author for copyediting corrections. The core content of an article cannot be changed at this time. It is the author's responsibility to check the entire manuscript, including tables, figure legends, and cited reference numbers, not just the items queried. The proofs should be corrected and mailed to the editorial office within 48 hours of receipt in order to expedite publication. Only one set of corrections will be accepted. In other words, it is important to ensure that all of your corrections are sent to us in one communication.
V. Â REPRINTS
Five free reprint copies of the published article will be shipped to the corresponding authors in Indonesia only, approximately two weeks after the issue is printed. Authors, including overseas authors, who wish to purchase reprints, are required to complete the Reprint Order Form, which will be sent with the galley proofs to corresponding authors. This form must be returned together with the corrected galley proofs.
