AKTIVITAS ANTIINFLAMASI NANOGEL EKSTRAKS ETANOL DAUN SUKUN PADA TIKUS PUTIH JANTAN YANG MENGALAMI LUKA BAKAR DERAJAT II
DOI:
https://doi.org/10.33143/jhtm.v11i1.5195Keywords:
Antiinflamasi, nanogel, daun sukunAbstract
AbstrakDaun sukun (Artocarpus altilis) mengandung metabolit sekunder yang berperan dalam mempercepat penutupan luka bakar. Nanogel merupakan salah satu bentuk sediaan farmasi yang meningkatkan absorpsi senyawa aktif melalui kulit. Penelitian ini bertujuan meguji aktivitas antiinflamasi sediaan nanogel dari ekstrak etanol daun sukun pada tikus putih jantan yang mengalami luka bakar derajat II. Pembuatan ekstrak etanol daun sukun diperoleh dengan cara maserasi menggunakan etanol 96% dan diuji karakteristik fisik sediaan, stabilitas, aktivitas antibakteri, iritasi dan penyembuhan luka bakar pada kulit tikus. Formulasi nanogel dibuat dalam 3 konsentrasi yaitu F1 (1,5625%), F2 (3,125%) dan F3 (6,25%). Secara histopatologi aktivitas antiinflamasi kelompok tikus yang diberi basis menunjukkan inflamasi yang berat dengan skor 3, F1 menunjukkan tingkat inflamasi yang sedang dengan skor 2, F2 menunjukkan inflamasi yang ringan dengan skor 1, dan F3 menunjukkan inflamasi yang sedang dengan skor 2. F2 menunjukkan persen penurunan diameter luka yang lebih cepat yaitu 92,84% dalam waktu 21 hari dibandingkan kelompok F1 dan F3 dengan persentase penyembuhan 81,14% dan konsentrasi 88,91% dalam waktu 21 hari.
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